DIFFERENCES B/W APOPTOSIS AND NECROSIS

 

FEATURE APOPTOSIS NECROSIS
Definition Programmed and coordinated cell death Cell death along with degradation of tissues by hydrolytic enzymes
Causative agents Physiological and pathological processes Hypoxia, toxins
Morphology ·         No inflammatory reaction

·         Death of single cell

·         Cell shrinkage

·         Cytoplasmic blebs on membrane

·         Apoptotic bodies

·         Chromatin condensation

·         Phagocytosis of apoptotic bodies by macrophages

·         Inflammatory reaction always present

·         Death of many adjacent cells

·         Cell swelling initially

·         Membrane disruption

·         Deranged organelles

·         Nuclear disruption

·         Phagocytosis of cell debris by macrophages

Molecular changes ·         Lysosomes and other organelles intact

·         Initiation of apoptosis by loss of signals of normal cell survival and by action of agents injurious to the cell

·         Triggered by intrinsic (mitochondrial) pathway (pro and anti-apoptotic members of Bcl-2 family), extrinsic (cell death receptor mediated) pathway

·         Lysosomes breakdown with liberation of hydrolytic enzymes

·         Initiated by various etiologies (ischemia, hypoxia, chemicals, physical agents, microbes)

·         Cell death by ATP depletion, membrane damage, free radical injury

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s